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RESEARCH PROGRAM:
This research is focused on better
understanding the neural systems mediating human learning,
memory, and emotion. Behavioral and functional MRI studies
from this laboratory investigate the acquisition,
expression, and extinction of human Pavlovian fear
conditioning. We are interested in the role of awareness in
the expression of fear-related behaviors, the neural
circuitry mediating aware and unaware fear memory processes,
and brain regions that process properties of fearful stimuli
compared to regions that produce behavioral and autonomic
fear responses.
REPRESENTATIVE PUBLICATIONS:
Knight, D. C., Smith,
C. N., Stein, E. A., & Helmstetter, F. J. (1999). Functional
MRI of human Pavlovian fear conditioning: Patterns of
activation as a function of learning. NeuroReport, 10 (17),
3665-3670.
Cheng, D. T., Knight, D. C., Smith, C. N., Stein, E. A., &
Helmstetter, F. J. (2003). Functional MRI of human amygdala
activity during Pavlovian fear conditioning: Stimulus
processing versus response expression. Behavioral
Neuroscience, 117 (1), 3-10.
Knight, D. C., Nguyen, H. T., & Bandettini, P. A. (2003).
Expression of conditional fear with and without awareness.
Proceedings of the National Academy of Sciences, 100 (25),
15280-15283.
Knight, D. C., Cheng, D. T., Smith, C. N., Stein, E. A., &
Helmstetter, F. J. (2004). Neural substrates mediating human
delay and trace fear conditioning. Journal of Neuroscience,
24 (1), 218-228.
Knight, D. C., Smith, C. N., Cheng, D. T., Stein, E. A., &
Helmstetter, F. J. (2004). Amygdala and hippocampal activity
during acquisition and extinction of human fear
conditioning. Cognitive, Affective, and Behavioral
Neuroscience, 4 (3), 317-325.
Haut, M., Kuwabara, H., Leach, S., Moran, M., Arias, R.,
Knight, D. (2005). The effect of education on age-related
functional activation during working memory. Aging,
Neuropsychology, and Cognition, 12, 216-229.
Knight, D. C., Nguyen, H. T., & Bandettini, P. A. (2005).
The role of the human amygdala in the production of
conditioned fear responses. NeuroImage, 26, 1193-1200.
Knight, D. C., Nguyen, H. T., & Bandettini, P. A. (2006).
The role of awareness in delay and trace fear conditioning
in humans. Cognitive, Affective, and Behavioral
Neuroscience, 5 (2), 157-162.
Cheng, D. T., Knight, D. C., Smith, C. N., Stein, E. A., &
Helmstetter, F. J. (2006). Human amygdala activity during
the expression of fear responses. Behavioral Neuroscience,
120 (6), 1187-1195.
Dunsmoor, J. E., Bandettini, P. A., & Knight, D. C. (In
Press). Impact of continuous versus intermittent CS-UCS
pairing on human brain activation. Behavioral Neuroscience.
Knight, D. C. Waters, N. S., & Bandettini, P. A.
(Submitted). Distinguishing the neural substrates of
declarative and nondeclarative fear memory.
Smith, C. N., Knight, D. C., Cheng, D. T., McIntosh, A. R.,
Chau, W. K., Stein, E. A., & Helmstetter, F. J. (In
Progress). Acquisition and reversal of differential fear
conditioning in humans using fMRI.
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