Email to:

arandich@uab.edu

Director's Site:

www.uab.edu/~wjpt//behneuro.html

Dr. Alan Randich

Professor / Director - Behavioral Neuroscience Program

EDUCATION:

Syracuse University, Psychology, B.A.,1972
Syracuse University, Experimental Psychology, M.S.,1975
Dalhousie University, Experimental Psychology, Ph.D.,1978
Yale University, Post-Doctoral Fellow, 1979

RESEARCH INTERESTS:

I have two primary research interests. One research interest is in pain and analgesia. Our laboratory has assessed many facets of this broad area including cardiovascular - pain regulatory interactions, brainstem neurons that modulate spinal cord processing of nociceptive input, and most recently, inflammation and the role of spinal prostaglandins in enhancing pain sensitivity. A second area of interest is in neural mechanisms involved in the regulations of food intake in animals and humans. Our laboratory examines how afferent nerves innervating the small intestine signal the brain about the presence of lipids, and then how this information engages systems that inhibit feeding.

REPRESENTATIVE PUBLICATIONS:

Randich, A., Tyler, W.J., Cox, J.E., Meller, S.T., Kelm, G.R., and Bharaj, S.S. (2000) Responses of celiac and cervical vagal afferents to infusions of lipids in the jejunum or ileum of the rat. American Journal of Physiology, 278, R34-R43.

Cox, J.E., Tyler, W.J., Randich, A., Kelm, G.R., Bharaj, S.S., Jandacek, R.J., and Meller, S.T. (2000) Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions. American Journal of Physiology, 278, R604-R610.

Ness, T.J., Fillingim, R.B., Randich, A., Backensto, E.M., and Faught, E. (2000) Low intensity vagal nerve stimulation lowers human thermal pain thresholds. Pain, 86, 81-85.

Spraggins, D. S., Turnbach, M.E., and Randich, A. (2001) Effects of glutamate receptor antagonists on spinal dorsal horn neurons during zymosan-induced inflammation in rats. Journal of Pain, 2, 12-24.

Turnbach, M.E. and Randich, A. (2001) The effect of spinal and systemic administration of indomethacin on zymosan-induced edema, mechanical hyperalgesia, and thermal hyperalgesia. Journal of Pain, 2, 25-35.

Ness,T.J., Randich, A., Fillingim, R.E., Faught, R.E. and Backensto,E.M. (2001) Left vagus nerve stimulation suppresses experimentally induced pan. (To the Editor), Neurology, 56, 985-986.

Cox, J.E., Tyler, W.J., Randich, A., Kelm, G.R., and Meller, S.T. (2001) Celiac vagotomy reduces suppression of feeding by jejunal fatty acid infusions. Neuroreport, 12, 1093-1096.

Randich, A., Spraggins, D.S., Cox, J.E., Meller, S.T. and Kelm, G.R. (2001) Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity. NeuroReport, 12, 3101-3105.

Turnbach, M.E.and Randich, A. (2002) The role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E2 or zymosan in the rat. Pain, In Press.

Turnbach, M.E., Spraggins, D.S. and Randich, A. (2002) Spinal administration of prostaglandin E2 and prostaglandin F2a in the rat: Behavioral and spinal neuronal responses. Pain, In Press.

Randich, A., Spraggins, D.S., Meller, S.T. Kelm, G.R., and Cox, J.E. (2002) Responses of hepatic and celiac vagal afferents to intraportal mercaptoacetate in rats red a high-fat or low-fat diet. NeuroReport, In press.

TEACHING INTERESTS:

Dr. Randich’s teaching interests include psychodynamics of pain, neurobiology of learning, and introduction to psychology.